Goserelin

Also Known As: Goserelin, Zoladex

Goserelin acetate (Zoladex, AstraZeneca) is an injectable gonadotropin releasing hormone superagonist (GnRH agonist), also known as a luteinizing hormone releasing hormone (LHRH) agonist. Structurally, it is a decapeptide. Goserelin acetate is used to suppress production of the sex hormones (testosterone and oestrogen), particularly in the treatment of breast and prostate cancer.

Goserelin acetate stimulates the production of the sex hormones testosterone and oestrogen in a non-pulsatile (non-physiological) manner. This causes the disruption of the endogenous hormonal feedback systems, resulting in the down-regulation of testosterone and oestrogen production.

Zoladex approved by the U.S. Food and Drug Administration in 1989 for treatment of prostate cancer.

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