Etodolac

Also Known As: Etodolac, Eccoxolac, Lodine, Lodine SR

Etodolac: Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to treat pain and fever in a way similar motrin.

Etodolac is manufactured by Almirall Limited under the trade name Lodine SR[4] and by Meda Pharmaceuticals under the name Eccoxolac.[5] Non-proprietary etodolac is also available

Post-marketing studies demonstrated that etodolac inhibition of cyclooxygenase is somewhat COX-2 selective similar to celecoxib and other "COX-2 inhibitors." Unlike rofecoxib, both etodolac and celecoxib can fully inhibit COX-1 and are designated as having "preferential selectivity" toward COX-2. Interestingly, the (inactive against COX) r-enantiomer of etodolac inhibits beta-catenin levels in hepatoma cells.

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