Apixaban

Also Known As: Eliquis, Apixaban

Apixaban (INN, trade name Eliquis) is an anticoagulant for the prevention of venous thromboembolism and the prevention of stroke in atrial fibrillation. It is a direct factor Xa inhibitor. Apixaban has been available in Europe since May 2011. The drug was developed in a joint venture by Pfizer and Bristol-Myers Squibb.[1][2]

Apixaban is a factor Xa inhibitor (anticoagulant) indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. [3] A systematic review of new anticoagulants states the treatment benefits of apixaban and other new anticoagulants compared with warfarin are small and vary depending on the control achieved by warfarin treatment.[4] Patients already taking warfarin with excellent international normalized ratio (INR) control may have little to gain by switching to new oral anticoagulants in atrial fibrillation.[5]

In Europe, apixaban is sometimes used to prevent the formation of blood clots in the veins (deep venous thrombosis) in adults who have had an operation to replace a hip or knee. In a systematic review of new oral anticoagulants (Noacs) against low-molecular-weight heparin (LMWH) there is marginal clinical benefit over LMWH and it is offset by increased risk for major bleeding. New oral anticoagulants have not been compared with warfarin.[6]

Apixaban is not indicated for prosthetic heart valves or for mitral stenosis.

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